The poll shows Clinton ahead by six points in a head-to-head match, 51-45, in a poll conducted in the four days following the final debate, hosted at the University of Nevada, Las Vegas.
When third-party candidates are included, Clinton leads 49-44, with Libertarian Gary Johnson behind at 3 percent and Green Party candidate Jill Stein at 2 percent.
Clinton's lead has not changed since CNN/ORC last polled likely voters nationwide in late September/early October, resting at +6 in the head-to-head match and +5 in a four-way poll.
The CNN/ORC poll was conducted via live telephone interview Oct. 20-23 among 779 likely voters nationally and has a margin of error of plus or minus 3.5 percent.
TPM's PollTracker Average for the general election shows Clinton leading Trump, 50.5 to 43.