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Sebelius: 'I Don't Work For' The People Who Want Me To Resign (VIDEO)

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AP Photo / J. Scott Applewhite

"The majority of people calling for me to resign, I would say, are people who I don’t work for, and who do not want this program to work in the first place," Sebelius said during a press conference at a call center in Phoenix, Ariz.

Republican lawmakers have clamored for Sebelius' resignation in the wake of the Obamacare web portal's glitchy rollout. A group of 32 House Republicans sent a letter to President Barack Obama Wednesday calling on him to ask Sebelius to step down.

Sebelius told CNN Tuesday that that she was "optimistic" that the website would operate smoothly, and said Obama didn't learn of its bugs until after the Oct. 1 launch.