Kelly ran down a list of statistics, including the disparity in employment between blacks and whites in Ferguson and that blacks are three times as likely as whites to be subjected to or threatened with force by police.
O'Reilly then challenged those numbers, claiming Attorney General Eric Holder really held the reins in the investigation into the fatal shooting of Brown, an unarmed black teenager, by a white police officer.
"I don't know why African-Americans wouldn't have confidence in that," he said. Kelly reminded him that Holder is running a satellite investigation to the primary inquiry being carried out in St. Louis County.
"It all comes down to family, culture, personal responsibility,” O'Reilly continued, contrasting black culture with what he called the "Asian success story." “All of these things which we don’t hear anything, or much about, and this is what drives the poverty.”
"It's not just family culture," Kelly countered.
"The black population feels forgotten, Bill. That's why they feel resentful," she added. "They don't believe the justice system is gonna give them a fair shake, they don't believe the economic system is gonna give them a fair shake. President Obama made all sorts of promises that didn't come through, their Democratic governor in Missouri made all sorts of promises that didn't come true. They have very few people to trust."
Watch below via Media Matters: