The bill, known as HB 2291, would, among other things, make it a Class 6 felony for a federal government employee or official to enforce federal laws or regulations of firearms, accessories, and ammunition that are owned or manufactured within state lines and remain within state lines.
The bill would also make any new federal laws restricting semi-automatic firearms and magazines, or requiring any form of firearm registration, unenforceable in Arizona.
Among the bill's sponsors is state Rep. Carl Seel (R), who previously made headlines as the author of a 2011 birther bill.
According to HB 2291's primary sponsor, the bill is designed to send a message to the President and Congress.
"Here's a line in the sand: Thanks, but no thanks. Stay out with your federal regulations you're going to impose on us," Rep. Steve Smith (R) told Capitol Media Services.
Arizona's lawmakers aren't the first to think of this kind of thing. As TPM reported earlier this month, similar noises have been made by Republicans in Mississippi, Texas, and Tennessee.
Read the full text of HB 2291 here.