During his speech, Graham lamented that Hillary Clinton is about to become president, blaming it on Republicans.
"How could that be? My party has gone batshit crazy," he explained.
He then joked about how much Senate Republicans dislike Sen. Ted Cruz (R-TX).
"If you kill Ted Cruz on the floor of the Senate, and the trial was in the Senate, nobody could convict you," he joked.
When it came time for Graham to joke and hurl insults at Donald Trump, the senator instead made some sobering remarks.
"I don’t know how I can best describe Donald Trump, but I can say this, that I don’t think he understands what makes America great. And I know I’m supposed to be funny, but I’m not really happy about where the country is right now," Graham said. "I could make a million Donald Trump jokes, and I have. But our party and our country is going to have to up its game."
Watch clips from Graham's speech via NBC News: