"I think Benghazi is gonna loom large in '14," Graham told Newsmax's Steve Malzberg on Wednesday.
"I think Democrats are gonna have to start making President Obama account for his leadership. Where was he that night? Did he know it was a terrorist attack? Why did he say for two weeks we think it was a protest? How could he have done that?"
A report from the Senate Intelligence Committee on Wednesday swatted down a number of popular right-wing conspiracy theories about Benghazi, but it did say the Sept. 11, 2012 attack was preventable.
It won't be the only issue Graham plans to exploit in his re-election campaign this year. He said last year that he hopes social issues like abortion figure prominently in 2014.