Clinton highlighted her breadth of policy experience in her closing statement in the PBS NewsHour debate, casting Sanders as a one-note candidate.
"We agree we've got to get unaccountable money out of politics. We agree that Wall Street should never again be allowed to wreck Main Street again," Clinton said. "But here's the point I want to make tonight. I am not a single-issue candidate, and I do not believe we live in a single-issue country."
Opponents have long criticized Sanders for his singular focus on income inequality and campaign finance reform, coupled with perceived shortcomings on foreign relations and national security issues.
Late last month, President Obama signaled support for Clinton with a veiled reference to Sanders in an interview, saying "the one thing everybody understands" about the presidency is "you don't have the the luxury of just focusing on one thing."