Clinton comes out ahead of Donald Trump among independents by four points, 39-35, in a head-to-head poll of the crucial voter demographic.
In a four-way ballot, Clinton still leads, 30-27, with Libertarian Gary Johnson following closely at 19 percent and Green Party candidate Jill Stein at 8 percent.
The former Secretary of State's lead with independent voters grew since Bloomberg last released a nationwide poll, conducted before the final presidential debate and FBI Director James Comey announced the agency would review a new batch of emails.
In mid-October, a Bloomberg/Selzer & Company poll showed Clinton polling a single point ahead among independent voters, 39-38, in a head-to-head match.
The Bloomberg Politics/Purple Strategies poll surveyed 601 likely independent voters nationwide via live telephone interview from Oct. 28-31, with a margin of error of plus or minus four percent.