Clinton leads by 11 points, 51-40, in the nationwide poll, conducted several days after the second presidential debate.
When third-party candidates are included, Clinton leads by nine points, 47-38, with Libertarian Gary Johnson polling at 8 percent and Green Party candidate Jill Stein at 3 percent.
The former Secretary of State has expanded her lead in the election since CBS polled the race just before the second debate on Oct. 4.
At the beginning of the month, Clinton was ahead +6 and now Clinton leads +11 in the head-to-head poll, and in the four-way match Clinton led +4 in early October and now she leads +9.
The CBS poll was conducted via live telephone interview on Oct. 12-16 among 1189 likely voters nationwide, and has a margin of error of plus or minus three percent.
TPM's PollTracker Average for the general election shows Clinton leading Trump, 49.2 to 41.5.