"I think the FBI director would like to indict both Huma and Hillary as we speak," the congressman told the Examiner at a debate-watch party for Sen. Marco Rubio (R-FL).
There is no evidence that the FBI is targeting Clinton with its investigation into the security of the private email server she used to conduct business as secretary of state. Last year, The New York Times erroneously reported the Justice Department was asked to open a criminal probe into Clinton's use of the private email server and added several corrections to the story.
Issa, who had led congressional investigations into the Benghazi attacks, told The Washington Examiner that FBI Director James Comey is "forced to triple-time make a case of what would otherwise be, what they call, a slam dunk."
"You can't have 1,300 highly sensitive emails that contain highly sensitive material that's taken all, or in part from classified documents, and have it be an accident," he continued. "There's no question, she knew she had a responsibility and she circumvented it."
Appearing Monday on Newsmax's "The Steve Malzberg Show," former House Majority Leader Tom DeLay (R-TX) also said that his "friends that are in the FBI" were "ready to indict" Clinton.