Nye will square off against creationist Ken Ham on Feb. 4 at the Petersburg, Ky. museum's Legacy Hall. The debate is titled: "Is creation a viable model of origins?”
In a statement on Thursday, Ham described the choice of Nye for a debate partner as a kind of natural selection.
“Having the opportunity to hold a cordial but spirited debate with such a well-known personality who is admired by so many young people will help bring the creation/evolution issue to the attention of many more people, including youngsters," Ham said in a statement on Thursday.
Ham also said that he hopes to show Nye around the museum, and introduce him to several museum staff members "who hold earned doctorates in science.”
Tickets to the event go on sale on Monday.
A recent Pew Research Center poll found 60 percent of American adults said they believe in evolution.