Clinton leads by 13 points, 54-41, in a head-to-head match against the businessman.
When third-party candidates are included, Clinton's lead increases slightly to 14 points, 51-37, with Libertarian Gary Johnson trailing at 6 percent and Green Party candidate Jill Stein at 2 percent.
The former Secretary of State's lead has risen significantly since AP/GfK last polled the nation in mid-September.
In a two-way race, Clinton led +6 in September which she increased to +13 today, and with third-party candidates, Clinton went from +6 in September to +14 today.
The AP/GfK poll was conducted online from Oct. 20-24 among 1,212 likely voters nationally, with a margin of error of plus or minus 3.1 percent.
TPM's PollTracker Average for the general election shows Clinton leading Trump, 49.2 to 40.6.