Clinton leads by six points, 50-44, in the head-to-head match among likely voters nationally.
When third party candidates are included, her lead expands to seven points, 47-40, with Libertarian Gary Johnson polling at 7 percent and Green Party candidate Jill Stein at 1 percent.
Clinton maintains a +6 lead in the head-to-head match nationally from Quinnipiac's last poll conducted in early October. In the four-way race, the former Secretary of State has expanded her lead slightly, from +5 earlier this month to +7 today.
The Quinnipiac University poll was conducted via live telephone interviews on Oct. 17-18 among 1,007 likely voters nationwide, and has a margin of error of plus or minus 3.1 percent.
TPM's PollTracker Average for the general election shows Clinton leading Trump, 47 to 41.4.