Police arrived at the couple's home in the Hyde Park neighborhood around 8:30 p.m. Monday after a report of shots fired, Officer Chris No said.
April Jace, 40, was found dead inside, officials said.
Michael Jace was taken into custody and booked early Tuesday on suspicion of homicide, No said. He was being held in a Los Angeles jail in lieu of $1 million bail. Calls from The Associated Press seeking comment from Jace'sagent and manager were not immediately returned Tuesday.
Coroner's officials were on the scene Tuesday morning in the quiet residential neighborhood.
Jace, 51, is best known for his role as LAPD Officer Julien Lowe in the TV series "The Shield." He also appeared on the show "Southland" and had small roles in the movies "Planet of the Apes," ''Boogie Nights" and "Forrest Gump."
Jace and his wife were married nine years and have two young sons. Lt. John Jenal said two children were at the single-family home at the time of the shooting. They were in protective custody this morning, he told City News Service.
Michael Jace was previously married to Jennifer Bitterman, but they divorced in 2002.
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Correction: Authorities say Michael Jace was arrested on suspicion of homicide; not charged with homicide. This story has been updated.