It was not immediately clear how many people were on board the aircraft, which a Federal Aviation Administration spokesman said appeared to be a Bombardier Challenger 600, a midsized private jet.
FAA spokesman Allen Kenitzer said the plane was headed from Tucson, Ariz., and crashed upon landing.
Attempts by The Associated Press to reach airport officials in Colorado and Arizona were not immediately successful.
Aspen is located in the Rocky Mountains about 100 miles southwest of Denver.
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