The biggest upsets on Obama's bracket are #13 Murray St. over #4 Vanderbilt and #13 Siena over #4 Purdue, both in Round 1.
He picked #12 Cornell to beat #5 Temple in Round 1, ascribing to the conventional wisdom that one #12 seed wins a game every year (Although you'd think a Columbia and Harvard man would never pick the Big Red to win anything).
Obama also appears to have a soft spot for #10 seeds. He slotted in round 1 wins for three of them: Missouri, Georgia Tech and St. Mary's.
Besides that, the President doesn't have much love for Cinderella. The lowest seed he has in the Sweet Sixteen is Marquette, a #6 seed.
Last year, Obama correctly picked the University of North Carolina to win the tournament, and, according to NESN, finished just above the 80th percentile in the ESPN Tournament Challenge.
Watch Obama make his picks: