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Senate Republican Leader Mitch McConnell issued the following statement regarding Senator-elect Scott Brown (R-MA). Here is the full text:

I want to congratulate Senator-elect Scott Brown on his decisive victory. There's a reason the nation was focused on this race: The voters in Massachusetts, like Americans everywhere, have made it abundantly clear where they stand on health care. They don't want this bill and want Washington to listen to them. Americans are investing their hopes in good Republican candidates to reverse a year-long Democrat trend of ignoring the American people on the issues of health care, spending and the growth of government.

The National Republican Senatorial Committee has released a statement congratulating Senator-Elect Scott Brown, saying the special Massachusetts election has put Democrats on notice for the 2010 midterms.

"As we look forward to the midterm elections this November, Democrats nationwide should be on notice: Americans are ready to hold the party in power accountable for their irresponsible spending and out-of-touch agenda, and they're ready for real change in Washington," said Sen. John Cornyn (R-TX), chairman of the NRSC.

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Less than 15 minutes after the race was called for Republican Scott Brown, the first of what could be many conservative Democrats asks for leadership to put the brakes on health care reform.

Sen. Jim Webb (D-VA) congratulated Brown on his win and delivered a zinger:

"In many ways the campaign in Massachusetts became a referendum not only on health care reform but also on the openness and integrity of our government process. It is vital that we restore the respect of the American people in our system of government and in our leaders. To that end, I believe it would only be fair and prudent that we suspend further votes on health care legislation until Senator-elect Brown is seated."

Democratic Senatorial Campaign Committee Chairman Robert Mendez just issued the following statement regarding the special election in Massachusetts. Here's the full text.

I have no interest in sugar coating what happened in Massachusetts. There is a lot of anxiety in the country right now. Americans are understandably impatient. The truth is Democrats understand the economic anger voters feel, that's in large part why we did well in 2006 and 2008.

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Massachusetts voters chose state Sen. Scott Brown as their next U.S. Senator, sending a Republican to replace the late Sen. Ted Kennedy and damaging the chances of passing health care bill that Democrats have spent months crafting.

The Associated Press and CNN declared Brown the victor over Attorney General Martha Coakley (D) with two-thirds of precincts reporting. (See returns here.) Kennedy held the seat 47 years until his death last summer.

It was the first statewide special election in the state's history, and unpredictable from the start. Democrats were caught off guard less than two weeks ago when polls showed Coakley, who had won the primary in December, had just a slim lead.

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Former DNC Chair Howard Dean told Rachel Maddow on MSNBC moments ago that Democrats aren't necessarily to blame for what seems like a likely loss in today's special senate election in Massachusetts.

"I certainly don't think it's a referendum on President Obama," Dean said.

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With the polls closed and a solid lead in the Massachusetts special Senate election, Scott Brown has tweeted his thanks to supporters.

"This was an amazing campaign and I appreciate your support. You were incredible," Brown said.

Brown, a Republican, is poised to win the seat that Democrat Ted Kennedy held for 47 years. He's currently leading Democrat Martha Coakley, the state attorney general, in the vote count.

Republican Scott Brown hit all the campaign's needed turnout projections and aides are confident he's racked up a win in Massachusetts, a former Republican National Committee official tells TPMDC.

The official suggested that the right cities and regions were coming in for Brown, while Boston returns weren't good enough for Democratic Attorney General Martha Coakley.

A Democratic source tells us operatives familiar with the state and keeping a close eye on returns think Brown will win with at least a 7-point margin.

No one has called the race yet. You can follow results live here.