President Obama and Mitt Romney participate in the first presidential debate in Denver at 7 p.m. MDT.
Vice President Joe Biden and Paul Ryan have no public events Wednesday.
First lady Michelle Obama will hold a rally in Reno, Nevada at 11:35 a.m. PDT before attending the debate in Denver.
Surrogates are also hitting the trail Wednesday.
Bill Clinton will stump for Obama in New Hampshire with an event at 12 p.m. EDT in Durham.
Sen. Marco Rubio will hold a rally in Denver for Romney at 10 a.m. MDT.
Sen. John McCain will hold a rally for Romney in Tallahassee, Florida at 11:30 a.m. EDT.